Consult the best chemotherapy doctor in Kolkata
This section describes the types of treatments, also called therapies, that are the standard of care for sarcoma. “Standard of care” refers to the best-known treatment. When developing a treatment plan, we encourage you to discuss the availability of clinical trials with your doctor. A clinical trial is a study that tests a new treatment. Doctors use clinical trials to determine if further treatments are safe, effective, and potentially better than standard treatments. Chemotherapy insertion specialists are doctors who treat patients suffering from deadly cancer disease.
Clinical trials can test new drugs, new combinations of standard treatments, or further doses of traditional medications or other therapies. One can consult a doctor to help you consider all your treatment options.
Learn more about clinical trials in this guide’s Clinical Trials and Latest Research section.
How are Sarcomas Treated?
Sarcomas are rare, and studies have shown that patients have a better prognosis if they are treated in a center experienced in the treatment of sarcomas.
These are called “Specialized Sarcoma Centres.”
In cancer treatment, different types of doctors often work together to develop a holistic treatment plan for patients that combines different treatments. This is called a multidisciplinary team. Cancer care groups incorporate other healthcare experts, counselors, pharmacists, workers, and other vital doctors.
Treatment plans and recommendations depend on many factors, including the type, stage, sarcoma grade, possible side effects, patient preferences, and general health.
Take the time to learn about all of your treatment options, and be sure to ask questions about unclear things. Talk to your doctor about the goals of each treatment and what to expect during your treatment. Such varieties of conversation are popularly known as joint decision-making.
Shared – the decision is when you and your doctor work together to choose the proper treatment for your treatment goals.
The common types of treatment used for sarcoma are described below. Your care plan can also incorporate treating symptoms and side effects vital to cancer treatment.
Therefore, this section cannot describe the best treatment for every rare sarcoma.
· Surgery
· Radiation therapy
· Chemotherapy
· Immunotherapy
· Targeted therapy
· Treatment by stage of sarcoma
· Remission and the chance of recurrence
· Organ transplantation
Signature Gene Expression in Ewing’s Sarcoma
Ewing’s sarcoma is an aggressive cancer that primarily affects adolescents. In most cases, the disease is caused by a fusion of the EWS and FLI1 genes, EWS-FLI1, which leads to extensive chromatin remodeling and generalized transcriptional dysregulation that promotes tumorigenesis and metastasis. Therefore, EWS-FLI1 is a potential therapeutic target.
Lurbinectedin (Zepzelca) selectively inhibits EWS-FLI1 by translocating it to the nucleolus and has been shown to slow tumor growth in a mouse model of Ewing’s sarcoma. Clinical Cancer Research has published the results of a recent phase II trial evaluating lurbinectedin in patients with recurrent Ewing’s sarcoma.
Approximately 57% of patients in the trial experienced some degree of disease control, and 14% had a clinical response to lurbinectedin. The median duration of response was 4.2 months, and patients were alive for a median of 12 months to the antitumor activity observed in this trial; the study authors suggest that lurbinectedin may be effective in combination with other therapies.
In Addition to Inhibiting EWS-
FLI1 itself, targeted modulation of fu
Sion proteins may be another therapeutic approach.
A recent study from Clinical Cancer Research revealed a new mechanism that regulates the activity of EWS-FLI1. It was previously known that high levels of EWS-FLI1 activity promote proliferation, while low activity leads to mesenchymal features and metastatic propensity. Additionally, previous studies have shown that expression of the transcription factor HOXD13 in Ewing’s sarcoma promotes metastasis, but the mechanism is still unclear.
Conclusion –
Although sarcomas are relatively rare, they can be devastating for patients diagnosed with them. Ongoing research will continue to uncover new treatment strategies to improve outcomes for people affected by these cancers. It is essential to contact the best chemotherapy doctors in Kolkata for the best cancer treatment.
FAQ –
Can sarcoma be cured completely?
If the sarcoma is detected early and has not spread where it started, surgery is often very effective, and many people recover. Instead, if the sarcoma expands to the rest of the body, the tumor can be controlled through treatments but cannot be cured entirely. Some sarcomas cannot be removed surgically.